HORDB

ID: hor004230
Uniprot ID: Q9GLN8
Protein name: Angiotensin-2
Gene name: AGT
Organism: Pan troglodytes (Chimpanzee)
Family: Serpin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Pan (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0004867 serine-type endopeptidase inhibitor activity
GO BP: GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0042310 vasoconstriction; GO:0042981 regulation of apoptotic process; GO:0097746 blood vessel diameter maintenance; GO:1901394 positive regulation of transforming growth factor beta1 activation
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: DRVYIHPF
Length: 8
Propeptide: MAPAGVSLRATILCLVAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAIFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDVQDNFSVTQVPFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRAIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
Signal peptide: MAPAGVSLRATILCLVAWAGLAAG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
Mechanism: NA
Cross BBB: NA
Target: AGTR2
Target Unid: A0A2I3S7W4
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004230_AF2.pdb

hor004230_ESM.pdb

Mass:	117123	Formula:	C50H71N13O12
Absent amino acids:	ACEGKLMNQSTW	Common amino acids:	DFHIPRVY
pI:	7.54	Basic residues:	2
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	-32.5	Boman Index:	-1650
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	85
Instability Index:	2580	Extinction Coefficient cystines:	1490
Absorbance 280nm:	212.86